The Gli1 gene was initially cloned as an amplified oncogene of a malignant glioma and then characterized as a transcription factor of the hedgehog signaling pathway [22, 23]. Three Gli proteins (Gli1, Gli2 and Gli3) are zinc-finger transcription factors and are expressed in vertebrates, in overlapping and partially redundant domains. These three proteins are Shh-dependent, where only Gli1 occurs as a full-length transcriptional activator, while Gli2 and Gli3 act as either a negative or positive regulators (Gli2A - Gli2 activated or Gli2R - Gli2 repressor and Gli3A - Gli3 activated or Gli3R - Gli3 repressor, respectively) of the pathway which is determined by post-transcriptional and post-translational processing [24, 25]. Moreover, the change of Gli3A to Gli3R form is favored with respect to Gli2. Consequently, Gli2 has mainly an activator transcriptional behavior, while Gli3 acts as a repressor [26]. It has already been demonstrated that Gli2 can accumulate in the primary cilium and controls transcriptional activation, in response to Shh ligand binding, overcoming thereby the negative regulation of Gli3 [27].
As Sonic escapes, the scene switches to the sight of a white-furred hedgehog named Silver, who speaks of finally locating the "Iblis Trigger". While running through the city, a confused Elise asks Sonic why he is helping her, but he replies that he has "no special reason". Soon afterward, more of Eggman's robots attack them, and Eggman successfully captures Elise in the Egg Mobile while Sonic is distracted fighting them. As Eggman returns to the Egg Carrier, Elise throws Sonic her Chaos Emerald, which he catches and assures her that he will rescue her. Unconcerned, Eggman simply decides to let Sonic hold onto the Emerald for the time being, and escapes on board the Egg Carrier as Sonic looks on.
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Sonic is a blue, 15-year-old hedgehog who lives on the planet Earth. He has the ability to run at supersonic speeds, hence his name. He is always running all over the world, rarely stopping for anything. He is carefree and relaxed; however, he is also very intolerant of injustice, and he will do anything he can to help those in need. He also has a quick wit, a short temper, and a fairly large ego. 2ff7e9595c
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